ABSTRACT
Monkeypox is an Orthopoxvirus, first documented as a human infection in 1970, with recent reemergence of infections despite increased understanding of this disease over the past 50 years. Human outbreaks of monkeypox, once endemic to Africa, are expanding worldwide due in part to increased geographic travel. The threat of this zoonotic disease becoming an international disaster is tangible, witnessed with viral conditions like H1N1 and COVID-19. It is paramount for health care personnel to be informed of recent monkeypox developments and understand optimal treatment and care of monkeypox-infected patients. This chapter reviews timely resources for medical providers to take appropriate precautions to prevent potential threats like a monkeypox attack.